成年人长期1型糖尿病的阶段角度和身体组成:巴西公共参考门诊诊所的一项比较研究
Natália Fenner-Pena1,2, Virgínia Capistrano Fajardo3, Lívia Froes4
1Diabetes Academic League-Borges da Costa Ambulatory, Type 1 Diabetes Section or Department of Clinical Medicine, Federal University of Minas Gerais-UFMG, Belo Horizonte, Brazil. natalia.fennerp@gmail.com.
与健康个体相比,1型糖尿病 (DM1) 患者的相角 (PA) 较低,表明细胞完整性较差,身体成分变化较差. 这些发现强调了在DM1管理中需要进行例行PA和身体成分评估的需要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 身体组成分析 身体成分分析
背景情况:
- 1型糖尿病 (DM1) 患病率正在增加,失控病例的数量越来越多.
- 通过生物电阻 (BIA) 测量的身体组成和相角 (PA) 是评估长期DM1患者细胞完整性和代谢控制的关键.
研究的目的:
- 为了比较患有1型糖尿病的成年人与健康对照者的PA和身体成分参数.
- 为了确定群体之间的身体部分和细胞完整性的潜在差异.
主要方法:
- 一项涉及成年DM1患者和年龄/性别匹配的健康对照 (2:1比率) 的比较研究.
- 评估人体测量 (体重,身高,BMI) 和BIA衍生的参数,包括PA,标准化PA (SPA),无脂肪质量 (FFM),脂肪质量 (FM),FFMI和FMI.
- 使用平均值/中位数比较和回归模型进行统计分析,以确定DM1组内的群体差异和关联 (HbA1c,疾病持续时间,并发症,葡萄糖,BMI,FMI).
主要成果:
- 评估了88名DM1患者和46名对照组.
- 与对照组相比,DM1患者的PA和SPA显著降低.
- 患有DM1的患者表现出较高的脂肪度 (%FM,FMI) 和较低的%FFM. 患有DM1的男性的FFMI比男性对照低.
结论:
- 患有DM1的患者呈现较低的PA,可能反映出受损的细胞膜完整性.
- 观察到显著的性别特异性身体组成差异:在DM1的女性中,脂肪度更高,在DM1的男性中,肌肉质量更低.
- 建议对DM1患者进行PA和身体组成的例行评估,以改善代谢控制和预后.
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