以色列过敏性鼻炎:在三个气候区进行过敏性鼻炎的多中心研究
Rachel Eisenberg1, Allon Raphael2, Matan Risling3
1Allergy and Immunology Unit, Shaare Zedek Medical Center, Jerusalem, Israel, Faculty of Medicine, Hadassah-Hebrew University School of Medicine, Jerusalem, Israel.
在以色列,86%的过敏性鼻炎患者的皮肤刺痛测试呈阳性. 虫,橄树花粉,草花粉和猫毛是最常见的触发因素,指导个性化免疫疗法.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 环境健康 环境健康
- 临床医学 临床医学
背景情况:
- 过敏性鼻炎 (AR) 影响全球人口的很大一部分,患病率差异很大.
- 尽管在以色列有其临床影响,但关于AR敏感性概况和关键气体过敏原的综合数据有限.
- 了解区域性空气过敏原的流行率对于有效的AR管理至关重要.
研究的目的:
- 为了确定最常见的气体过敏原,在以色列多样化的气候区的过敏性鼻炎患者中引起阳性皮肤刺伤测试 (SPT).
- 提供数据,可以为以色列人口中AR的诊断和治疗策略提供信息.
主要方法:
- 对1308名被诊断患有过敏性鼻炎 (AR) 的患者进行了皮肤刺伤测试 (SPT) 评估.
- 从以色列三个不同的地形和气候区域收集了数据,考虑了湿度,温度和城市化等因素.
- 分析了对各种空气过敏原的敏感性概况.
主要成果:
- 在AR患者中观察到阳性SPT的总体患病率很高 (86%).
- 在76%的患者中报告了室内空气过敏原敏感性,其中20%的单敏感性和65%的多敏感性.
- 发现的最常见的敏感性空气过敏原是虫,橄树花粉,草花粉和猫头,区域差异可见.
结论:
- 虫,橄树花粉,草花粉和猫头是以色列引发过敏性鼻炎的主要气体过敏原.
- 识别这些关键的空气过敏原可以定制SPT面板,并选择用于免疫治疗的特定过敏原.
- 这项研究为定制以色列AR管理策略提供了有价值的见解,该策略基于普遍存在的当地空气过敏原.
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