血红蛋白与红细胞分布宽度比率与慢性病之间的关联:一个截面研究
Lin Ning1, Junping Tang, Zhiqiang Chen
1Department of Nephrology, Yuebei People's Hospital, Shaoguan, China.
Medicine
|November 13, 2024
概括
血红蛋白与红细胞分布宽度比 (HRR) 与慢性病 (CKD) 的较低患病率有关. 较高的HRR表明美国成年人患CKD的风险降低.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 血红蛋白与红细胞分布宽度比 (HRR) 是一个新兴的预后生物标志物.
- 关于HRR和慢性病 (CKD) 之间的关联,研究有限.
研究的目的:
- 调查HRR与美国大量成年人群中CKD患病率之间的关系.
- 确定HRR是否可以作为CKD的预测指标.
主要方法:
- 利用了来自国家健康和营养检查调查 (2005-2018) 的数据.
- 包括19426名年龄≥20岁的参与者,具有完整的HRR和CKD数据.
- 采用加权单变量,多变量逻辑回归,受限立方线和子组分析.
主要成果:
- 经过对混杂因素进行调整后,发现HRR和CKD流行率 (OR=0.35,95%CI=0.22-0.56) 之间存在显著的负相关性.
- 限制性立方脊线分析证实了负线性关系,较高的HRR与较低的CKD患病率有关.
- 反向关联在男性中更为明显.
结论:
- HRR与美国成年人中CKD患病率有负面关联.
- HRR显示出作为评估CKD患病率和指导个性化管理策略的指标的潜力.
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