相关实验视频
Updated: Jun 7, 2025
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
在先天性甲状腺功能低下症查中,理想的甲状腺刺激激素 (TSH) 值是多少? 双胞胎研究 双胞胎研究
Fatih Kurt1, Busra Olcay Oz2, Abdulkadir Kaya3
1Duzce University, Pediatrics Clinic, Duzce, Turkey.
Medicine
|November 13, 2024
概括
出生性甲状腺功能低下症查使用甲状腺刺激激素 (TSH) 值. 这项双胞胎研究发现,与低于这一值的婴儿相比,TSH水平≥8mU/L的婴儿长期没有显著的发育差异.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 遗传性甲状腺功能低下症是智力障碍的主要可预防的原因.
- 通过新生儿查计划进行早期诊断对于及时干预至关重要.
- 目前的查协议使用甲状腺刺激激素 (TSH) 值,但对理想值缺乏共识.
研究的目的:
- 在先天性甲状腺功能低下症查中研究甲状腺刺激激素 (TSH) 值为8mU/L的长期影响.
- 为了比较双胞胎的体质生长,精神发育和神经运动发育,具有不同的TSH水平.
主要方法:
- 进行了一项双胞胎研究,涉及8对双胞胎,其中一个双胞胎的血TSH≥8mU/L,另一个<8mU/L.
- 收集的数据包括年龄,性别,妊娠周,出生体重,身高,体重和初始TSH值.
- 使用丹佛发育测试评估了血维生素B12,叶酸,25-OH维生素D,费里丁,血红蛋白和发育结果.
主要成果:
- 在TSH水平≥8mU/L的双胞胎和TSH水平<8mU/L的双胞胎之间,没有观察到对体生长的长期显著损害.
- 精神发育和神经运动发育在比较的双胞胎组之间没有显著差异.
- 该研究表明,8mU/L的TSH值可能不会导致可检测的长期发育缺陷.
结论:
- 在新生儿对先天性甲状腺功能低下症的查中,甲状腺刺激激素 (TSH) 值为8mU/L,在长期的体力,精神和神经运动发育方面似乎是安全的.
- 需要对更大的双胞胎队伍进行进一步的研究来证实这些发现.
- 这项研究有助于正在进行的关于优化先天性甲状腺功能低下症查方案的讨论.
更多相关视频
14:01Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
14.5K
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
2.4K
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
01:26Pulmonary Tuberculosis IV
133
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
133
01:18Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K