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关于内分泌相关疾病中维生素D缺乏和维生素D受体多态性的综述

Nur Faten Hafizah Rosli¹, Noor Shafina Mohd Nor^1,2,3, Rose Adzrianee Adnan⁴

¹Institute of Medical Molecular Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Sungai Buloh, Jalan Hospital, Sungai Buloh, Malaysia.

Clinical and experimental pediatrics

|November 13, 2024

概括

维生素D缺乏症在儿童和青少年中很常见,影响生长和免疫力. 本综述探讨了维生素D受体 (VDR) 基因变异如何影响年轻人群中的这些健康结果.

科学领域:

内分泌学在内分泌学.
遗传学遗传学是一个
儿科儿科儿科

背景情况:

皮肤充当外周内分泌器官,在暴露在阳光下合成维生素D.
维生素D在许多生理过程中起着至关重要的作用,其作用由维生素D受体 (VDR) 介导.
维生素D缺乏症在儿童和青少年中越来越普遍,与各种健康问题有关.

研究的目的:

审查维生素D内分泌系统,VDR基因多态性和儿童和青少年健康之间的联系.
阐明VDR基因变异对儿童群体生长,青春期,胰岛素耐药性和免疫功能的影响.
解决影响VDR多形态-疾病关联的地理和种族差异.

主要方法:

文献综述侧重于有关维生素D,VDR基因和儿科健康的研究.
对研究的分析,研究了VDR多态性和儿童和青少年内分泌相关疾病之间的关系.
综合了关于维生素D及其受体的类作用的数据.

主要成果:

在不同的人群中,VDR基因多态表现出与维生素D内分泌疾病的可变关联.
地理和种族因素有助于VDR多态效应的异质性.
维生素D缺乏和VDR基因变异会影响儿科生长,青春期发育,胰岛素抵抗和免疫反应.

结论:

VDR基因多态是儿童维生素D内分泌健康的重要因素.
了解这些遗传变异对于解决儿童和青少年的健康差异和疾病发展至关重要.
需要进一步的研究来澄清群体特定的VDR多态性对儿科健康结果的影响.

关键词:

这是一种自身免疫力.内分泌系统内分泌系统内分泌系统胰岛素耐药性胰岛素耐药性是一种多态性多态性多态性维生素D 维生素D是一种维生素.

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