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Updated: Jun 7, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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作为RNA结合剂的Azaspirocycles的设计和评估

Claire Fleurisson1, Nessrine Graidia1, Jihed Azzouz2

  • 1Université Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, F-75006, Paris, France.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 13, 2024
PubMed
概括

研究人员开发了新方法来合成独特的阿扎斯皮罗环. 其中一些化合物显示为HIV-1 TAR RNA的结合剂,可能有助于药物发现.

关键词:
结合RNA的小分子.TAT/TAR相互作用抑制剂亚萨斯皮罗循环环的使用.双循环的水酸盐.三维分子结构是三维的分子结构.

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相关概念视频

Ribozymes02:47

Ribozymes

The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
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