改变了内在神经活动及其分子分析在第一发精神分裂症与听觉口头幻觉
Ziyu Wang1,2, Kangkang Xue1,2, Yimeng Kang1,2
1Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
精神分裂症的听觉语言幻觉 (AVH) 与特定区域的大脑活动减少有关. 这些变化与多巴胺,血清素和上腺素水平相关,为AVH机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 听觉语言幻觉 (AVH) 是精神分裂症的核心症状,严重影响患者的生活.
- 异常局部大脑活动与AVH有关,但其与特定神经递质系统的联系尚不清楚.
- 了解AVH的神经生物学基础对于开发有效治疗方法至关重要.
研究的目的:
- 为了研究精神分裂症患者经历AVHs的改变内在大脑活动.
- 探索AVH中内在大脑活动和神经递质系统之间的相关性.
- 为了提高对AVH神经生物学机制的理解,在第一期,药物先天精神分裂症患者.
主要方法:
- 包括50名第一发,先前没有服用过药物的精神分裂症患者,有AVH,50名没有AVH (NAVH) 和50名健康对照 (HC).
- 利用低频波动的幅度 (ALFF) 来评估内在的大脑活动.
- 空间相关的改变ALFF与神经递质图 (多巴胺,血清素,上腺素) 使用JuSpace.
主要成果:
- 与HC相比,AVH组在包括前骨,补充运动区域和前中心/后中心旋转区域的区域显著减少了ALFF.
- 与HC相比,NAVH组在头和骨区域呈现较低的ALFF.
- 与NAVH组相比,AVH组在右下额头环中具有更高的ALFF,与多巴胺,血清素和上腺素相关的变化.
结论:
- 这项研究将神经递质系统与精神分裂症患者的异常内在大脑活动联系起来.
- 这些发现有助于全面了解AVH病理生理学.
- 确定的神经生物学相关物可能会为未来的AVH治疗策略提供信息.
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