抗生素污染物及其在德切里金吉河的影响:从SPE-UPLC-MS/MS和斑马鱼研究的见解
Patharaj Gokul1, Murugesan Sobanaa2, S Hari Krishna Kumar2
1Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi-221005, Uttar Pradesh, India.
Toxicology research
|November 13, 2024
概括
吉吉河中的抗生素残留物与耐药细菌有关,并构成健康风险. 这项研究量化了五种抗生素,并发现它们在环境度下对斑马鱼有毒.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 生态系统中的抗生素残留物有助于抗生素耐药性,影响人类和动物的健康.
- 了解水体中的抗生素存在对于评估环境和健康风险至关重要.
研究的目的:
- 量化Gingee河中的多类抗生素残留物.
- 研究抗生素存在与抗生素耐药细菌之间的关系.
- 在斑马鱼模型中评估抗生素的发育毒性.
主要方法:
- 固相提取 (SPE) 与超高性能液体染色学质谱学 (UPLC-MS/MS) 结合用于抗生素量化.
- 对水样品进行微生物分析,以确定占主导地位的细菌物种.
- 使用暴露于环境相关抗生素度的斑马鱼进行发育毒性评估.
主要成果:
- 在金吉河水中检测到五种抗生素,其中纳利迪克酸,硫甲醇和四环环素分别为8.5,6.9和4.8μg/L.
- 甲尼达和三甲胺被发现低于可量化的限值.
- 希格拉 (Shigella sp.) 是一种植物. 和 Acinetobacter sp. 这种细菌. 是最常见的细菌;斑马鱼研究证实了抗生素的亚致命毒性.
结论:
- 这项研究提供了第一份关于金吉河抗生素度的报告,强调了抗生素残留物和耐药细菌之间的联系.
- 这些抗生素的环境相关度对人类健康构成潜在的危害,斑马鱼研究证实了这一点.
- 综合方法对于了解抗生素残留物对环境的影响,它们在耐药性演变中的作用以及它们对人类健康的影响至关重要.
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