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在COVID-19相关的多系统炎症综合征的儿科患者中,甲状腺功能和脂质动脉动脉基因特征之间的关系
Valeria Calcaterra1,2, Raffaella De Santis2, Davide Braghieri2
1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Frontiers in pediatrics
|November 13, 2024
概括
甲状腺功能障碍与患有多系统炎症综合征 (MIS-C) 的儿童的异位性脂质特征有关. 虽然甲状腺功能在12个月后恢复正常,但一些患者的脂质样本仍然有所改变.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 评估心血管风险评估
- 传染性疾病 传染性疾病
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 与代谢障碍和甲状腺功能障碍有关,包括非甲状腺疾病综合征 (NTIS).
- 甲状腺激素 (TH) 在调节脂质代谢方面发挥着至关重要的作用.
研究的目的:
- 研究诊断为MIS-C.的儿童甲状腺功能与异位性脂质样本之间的关系.
- 在入院和12个月的随访期间评估这些参数.
主要方法:
- 研究了56名接受MIS-C治疗的儿童.
- 在入院和随访期间评估脂质特征 (总胆固醇,HDL,甘油三) 和甲状腺功能标志物 (自由T3,自由T4,TSH).
- 计算的动脉质风险标志物,如TG/HDL比率,非HDL/HDL比率,以及动脉质血指数 (AIP).
主要成果:
- 在入院时,患有MIS-C的儿童显示FT3,FT4,TSH,TG,TC,HDL,TG/HDL比率,非-HDL/HDL比率和AIP的异常水平.
- 相关性分析表明FT3,FT4和脂质标志物之间以及TSH和TG之间存在关联.
- 在12个月的随访后,甲状腺功能正常化,但一些患者仍然有改变的脂质样本,没有观察到与甲状腺功能的相关性.
结论:
- 研究结果支持甲状腺功能与小儿MIS-C中的异位性脂质样本之间的联系.
- 这种关联可能源于代谢反应,先天免疫力和遗传因素之间的相互作用.
- 了解感染期间的TH代谢途径相互作用,可以确定改善MIS-C患者预后和长期健康的生物标志物.
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