基于染料的染色内镜检测出更多的瘤比白光内镜在患有原发性硬化胆管炎和IBD的患者
Rodrigo V Motta1, Vipin Gupta2, Karen Hartery3
1Translational Gastroenterology and Liver Unit, Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland.
Endoscopy international open
|November 13, 2024
概括
染色内镜显著改善了原发性硬化胆管炎和炎症性肠病 (IBD) 患者的瘤检测. 这种技术提高了对结肠直肠癌风险的监测,即使使用高清结肠镜.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内镜检查是指内镜检查.
背景情况:
- 患有原发性硬化性胆道炎 (PSC) 和炎症性肠病 (IBD) 的患者面临着结直肠癌 (CRC) 的风险增加.
- 在这个高风险人群中,目前对结直肠瘤的监测策略缺乏标准化的共识.
- 有效的检测方法对于早期干预和改善患者结果至关重要.
研究的目的:
- 评估染色内镜和/或高清内镜与结直肠瘤检测率之间的关联.
- 为了比较经过这些先进的内镜技术和没有这些先进的内镜技术进行监测的PSC患者的瘤检测率.
- 确定PSC-IBD患者监测的最有效的内镜方法.
主要方法:
- 一项单中心,回顾性,观察性研究分析了2010年至2020年期间91名PSC和IBD患者的359个结肠镜.
- 在标准和先进的内镜技术 (染色内镜,HD内镜) 之间比较了瘤检测率 (腺瘤和状).
- 使用多级逻辑回归来调整潜在的混因素.
主要成果:
- 总体而言,有24%的患者在研究期间至少发现了一种瘤病变.
- 染色内镜检测显示,瘤的检测率显著更高 (OR 5.58,P=0.001),即使经过对HD内镜进行调整.
- 虽然HD内镜显示出更高检测的趋势,但在调整为染色内镜后 (OR 1.93,P=0.21) 这没有达到统计学意义.
结论:
- 染色内镜是提高PSC和IBD患者瘤检测的宝贵工具.
- 在对结直肠瘤的监测中,染色内镜的好处是显而易见的,无论使用高清结直肠镜.
- 这些发现支持将染色内镜纳入高风险PSC-IBD患者的监测方案.
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