维生素D的超重老年人降低血压:一项随机试验
Maya Rahme1, Laila Al-Shaar2, Hani Tamim3,4
1Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.
Journal of the Endocrine Society
|November 13, 2024
概括
维生素D和补充剂可以降低年龄较大,超重的成年人的血压 (BP). 在BMI超过30的个体和高血压患者中,无论维生素D的剂量如何,都观察到这些益处.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 营养科学 营养科学
背景情况:
- 维生素D在血压调节中的作用尚不清楚,有相互矛盾的证据.
- 与一起补充胆胺 (维生素D3),正在研究其对血压结果的潜在影响.
研究的目的:
- 为了检查两种不同剂量的维生素D3和对静缩血压 (SBP) 和静缩血压 (DBP) 的影响.
- 分析这些影响在门诊,老年,超重个体,包括肥胖和高血压的子组.
主要方法:
- 一年多的多中心,双盲,随机对照试验 (RCT) 涉及221名参与者.
- 参与者在每天600 IU或每天3750 IU的维生素D3中获得.
- 探索性分析评估了基于BMI和高血压状态的血压变化.
主要成果:
- 总体而言,观察到SBP和DBP的显著下降. 高剂量维生素D组在6个月和12个月后显著减少.
- 在BMI>30的参与者中,SBP在两组都显著下降,而DBP仅在高剂量组显著下降.
- 患有高血压的参与者 (N=143) 经历了显著的SBP和DBP降低与两个剂量,无论BMI.
结论:
- 维生素D和补充剂有效降低超重的老年人SBP和DBP.
- 特别是在BMI>30和高血压患者中,人们特别注意到这种有益影响.
- 更高剂量的维生素D并不一定带来更大的益处;效果似乎在很大程度上与剂量无关.
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