绘制肝脏衰老研究演变的地图:一个图书统计分析
Qun-Hua Han1,2,3, Shun-Mei Huang1,2, Sha-Sha Wu1,2,4
1Department of Geriatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
World journal of gastroenterology
|November 13, 2024
概括
这种图书统计分析揭示了肝脏衰老的关键研究趋势和热点,确定了重要的基因和途径. 它为未来关于健康衰老和与年龄相关的肝病的研究提供了路线图.
科学领域:
- 老年学是指老年学的学科.
- 肝病学 肝病学是一种肝病学.
- 图书统计学 图书统计学
背景情况:
- 全球人口老龄化需要对健康老龄化和与年龄有关的疾病进行研究.
- 肝脏在衰老过程中在新陈代谢,解毒和免疫系统中发挥着关键作用.
- 迄今为止,没有任何先前的文献计量分析能够全面评估肝脏衰老研究的科学进展.
研究的目的:
- 进行对肝脏衰老研究的文献分析.
- 识别基础知识,发展趋势和新兴的研究前沿.
- 为了绘制肝脏衰老的科学景观.
主要方法:
- 使用Python,R (bibliometrix),CiteSpace和VOSviewer进行图书法测量分析.
- 数据来源于科学网络核心集合的数据.
- 作者,期刊,国家,机构,关键词和共同引用的参考文献的知识映射.
- 通过STRING数据库分析基因调节途径.
主要成果:
- 在1991年至2020年之间发表了4288篇文章,在1991年和2020年出现了显著的爆发.
- 美国在出版物,引用和国际合作方面处于领先地位.
- 主要的关键词包括"脂质代谢"",脂肪肝病"",炎症"和"肝纤维化".
- 已确定的前64个基因参与了关键的衰老途径,如PI3K/AKT,FOXO和p53信号传递.
结论:
- 这项研究提供了肝脏衰老研究的全面概述.
- 它强调了未来研究的关键研究领域和趋势.
- 提供了潜在的合作和健康衰老的临床应用的见解.
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