衰老和炎症衰老与男性内皮功能障碍有关,但与动脉样硬化症的女性无关
Pauline Mury1,2, Gael Cagnone3, Olina Dagher1,2,4
1Montreal Heart Institute Research Center, University of Montreal, Montreal, Quebec, Canada.
JACC. Basic to translational science
|November 13, 2024
概括
冠状动脉疾病 (CAD) 的风险因男性早期的内皮功能障碍而因性别而异. 男性内皮细胞的炎症表明,老年化药物可能对患有CAD的女性不那么有效.
科学领域:
- 心血管科学 心血管科学
- 分子生物学分子生物学
- 衰老研究研究 衰老研究
背景情况:
- 冠状动脉疾病 (CAD) 显示出显著的两性变异,男性更早出现.
- 内皮功能障碍是CAD的前体,在中年男性中比女性早大约10年发展.
研究的目的:
- 调查冠状动脉疾病 (CAD) 中基于性别的差异的分子基础.
- 探索导致男性CAD早期发病的内皮细胞特征.
主要方法:
- 从接受CAD手术的患者的动脉细分的ex vivo分析.
- 对内皮细胞进行转录分析,以识别分子特征.
- 对内皮放松剂敏感性的评估.
主要成果:
- 与女性相比,男性表现出较低的内皮松剂敏感性.
- 男性的内皮细胞表现出与衰老和炎症相关的转录基因特征.
- 女性的内皮细胞维持与细胞代谢和维护相关的途径.
结论:
- 基于性别的CAD患病率差异与独特的内皮细胞分子谱有关.
- 男性内皮细胞的衰老和炎症可能解释了早期的疾病发作.
- 针对心血管事件的老化疗法可能在CAD患者的性别之间具有差异性疗效.
更多相关视频
08:41Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
9.8K
06:04Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
805
相关概念视频
Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37
Inflammation
52.8K
Overview
52.8K
Menopause
140
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
140
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
