风湿性关节炎患者的肠道透性:一个关键的治疗优先事项
Thomas G Guilliams1, Jill L Weintraub2, Myles Spar3
1Scientific Director, AndHealth, Columbus, Ohio; Founder and Director of the Point Institute, Stevens Point, Wisconsin; Adjunct Associate Professor, School of Pharmacy, University of Wisconsin-Madison.
肠道透性或漏肠的生物标志物与类风湿性关节炎有关. 准肠道屏障功能可能有助于管理这种免疫媒介炎症性疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种影响关节的免疫媒介炎症性疾病 (IMID).
- 关节炎治疗的进步准了下游的炎症媒介,如细胞因子和Janus 激酶 (JAK) 抑制剂.
- 较少的进展解决了IMID的上游触发因素,例如肠道过性 (漏肠) 和肠道失生症.
研究的目的:
- 审查肠道透性生物标志物和非胃肠道IMID之间的关联.
- 在诸如类风湿性关节炎等疾病中突出显示肠关节轴.
- 探索在RA治疗中准肠道屏障功能的潜力.
主要方法:
- 现有文献的叙述性审查.
- 讨论IMIDs常见的免疫信号通路.
- 分析肠道健康和全身炎症之间的联系.
主要成果:
- 肠道过性是各种慢性疾病的前身,包括RA.
- 肠道透性的生物标志物经常与非胃肠道IMID相关.
- 肠-关节轴在RA的发病过程中越来越被认可.
结论:
- 肠道透性的测量与类风湿性关节炎有关.
- 针对肠道屏障功能的干预措施可能有助于RA患者.
- 解决肠道健康问题可能是RA缓解的辅助策略.
更多相关视频
09:24Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
