在OncoSexome:基于性别的差异在瘤疾病的景观
Xinyi Shen1,2, Yintao Zhang1, Jiamin Li3
1College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou 310058, China.
Nucleic acids research
|November 13, 2024
概括
OncoSexome是一个新的知识库,详细介绍了癌症的性别差异,包括药物,生物标志物,危险因素和微生物. 本资源支持性别特定的精确瘤学,强调了对癌症的关键生物学性别影响.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 生物信息学是一种生物信息学.
背景情况:
- 美国国家卫生研究院关于性别作为生物变量 (SABV) 的政策强调了精确瘤学的基于性别的差异.
- 超过50%的可操作的瘤基因表现出性别偏见,影响药物的疗效.
- 在非生殖癌症中观察到性别差异,因此需要性别特定的数据.
研究的目的:
- 开发OncoSexome,一个关于癌症性别差异的全面知识库.
- 整合有关性别差异性抗瘤药物和反应 (SDR) 的数据.
- 收集有关癌症性别差异生物标志物 (SBM),风险因素 (SRF) 和微生物景观 (SML) 的信息.
主要方法:
- 开发了OncoSexome,一个多维知识库.
- 在四个关键主题中对基于性别的差异进行了分类:SDR,SBM,SRF和SML.
- 包括2051种抗癌药物,12551种生物标志物,350种风险因素和1386种微生物的数据.
主要成果:
- OncoSexome详细介绍了抗癌药物的性别差异,生物标志物,风险因素和微生物与癌症的关联.
- 该数据库涵盖2051种药物,12551种生物标志物,350种风险因素和1386种微生物.
- 它阐明了生物性别对癌症的多方面的影响,包括外部和内源因素.
结论:
- OncoSexome是一个独特的资源,用于了解基于性别的癌症影响.
- 它提供了跨主要瘤学类别的性别差异的广泛概述.
- 该知识库预计将对未来的精确瘤学实践产生重大影响.
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