糖尿病预测中的精准医学:探索风险分层化的子组特定生物标志物策略
I-Weng Yen1,2, Szu-Chi Chen3, Chia-Hung Lin4
1Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu County, Taiwan.
Journal of diabetes investigation
|November 13, 2024
概括
一个新的子组特定生物标志物策略改善了2型糖尿病的预测. 根据性别和BMI量身定制生物标志物提高了准确性,有助于早期发现高风险个体.
科学领域:
- 发现生物标志物的发现.
- 糖尿病流行病学 糖尿病流行病学
- 预防医学 预防医学
背景情况:
- 早期发现高风险个体对于延迟和减少2型糖尿病发病率至关重要.
- 需要新的生物标志物策略来更好地预测发生的糖尿病.
研究的目的:
- 探索一种新的子组特定生物标志物策略在预测2型糖尿病事件中的性能.
- 评估不同亚组中特定生物标志物 (SCG3,VAP-1,FGL1,ANGPTL6,ANGPTL4) 的预测值.
主要方法:
- 台湾生活方式队列研究包括1287名非糖尿病成年人,从2006年至2019年进行了跟踪.
- 测量的生物标志物包括秘素III (SCG3),血管粘附蛋白-1 (VAP-1),纤维素样蛋白1 (FGL1),血管类蛋白6 (ANGPTL6) 和血管类蛋白4 (ANGPTL4).
- 开发和比较子组特定的生物标志物策略与全人口策略.
主要成果:
- 12.2%的受试者在随访期间患上了糖尿病.
- 血管粘附蛋白-1 (VAP-1) 预测了一般人群,年轻人 (<65岁),BMI≥24kg/m2的人和女性的发生糖尿病.
- 血管类蛋白6 (ANGPTL6) 预测了老年人 (≥65岁) 的糖尿病,而秘素III (SCG3) 预测了BMI <24 kg/m2.3 个体的糖尿病.
- 一个针对性别和BMI的特定生物标志物策略改善了预测性能,特别是特异性和积极的预测值.
结论:
- 一个特定于性别和BMI的生物标志物策略显著提高了发生2型糖尿病的预测.
- 特定子组生物标志物策略代表了预测糖尿病发病率的新有效方法.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Management and Pharmacotherapy
236
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
236
Diabetes: Symptoms, Diagnosis, and Complications
508
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
508
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


