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设计一种基于分子印记的聚合物电化学传感器,用于敏感和选择性地检测抗疟疾药物酸

Ensar Piskin^1,2, Ahmet Cetinkaya¹, Mehmet Altay Unal³

¹Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, Türkiye.

Mikrochimica acta

|November 13, 2024

概括

使用纳米材料支持的分子印记聚合物 (MIPs) 的新型电化学传感器提供了对酸 (CHL) 的敏感和特定检测. 这一进步在各种样本中提供了非常精确的CHL量化,具有很好的选择性.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
分析化学分析化学

背景情况:

开发敏感和特定的分析方法对于药物监测至关重要.
分子印记聚合物 (MIP) 为目标分析物提供了量身定制的识别点.
纳米材料可以提高电化学传感器的性能.

研究的目的:

开发一种新的电化学传感器,用于敏感和特异性地测定黄酸盐 (CHL).
用纳米材料支持的MIP来提高传感器性能.
为了验证传感器在复杂矩阵 (如血清和制药配方) 中的有效性.

主要方法:

在玻璃碳电极 (GCE) 上通过电聚合制造基于MIP的电化学传感器.
纳入普鲁士蓝色聚乙烯甘胺纳米颗粒 (PB@PEG-NH2) 来增强表面积和多孔性.
使用电化学阻抗光谱 (EIS),循环电压测量 (CV) 和扫描电子显微镜 (SEM) 的表征.
使用微分脉冲电量计 (DPV) 在[Fe(CN) 6]3-/4-氧化还原探针溶液中量化CHL.

主要成果:

开发的传感器 (CHL/AMPS-PANI/PB@PEG-NH2/MIP-GCE) 显示了CHL的广泛线性响应范围,从1.75 × 10−12到2.50 × 10−13M.
实现了6.68 × 10−14 M的超低检测极限 (LOD) 和2.23 × 10−13 M的量化极限 (LOQ).
在增值血清和药片样本中,证明了高恢复率 (99.13101.51%) 和较低的相对标准偏差 (<2.41%).
在存在结构相似的化合物时表现出极好的选择性.

结论:

纳米材料支持的MIP电化学传感器为CHL确定提供了一个高度敏感,特定和可靠的平台.
传感器在复杂矩阵中的性能表明其在制药分析和临床诊断中的真实应用潜力.
整合PB@PEG-NH2纳米颗粒对增强的传感能力作出了重大贡献.

关键词:

氨酸酸的含量是多少微分脉冲电压测量微分脉冲电压测量电化学传感器是一种电化学传感器.疟疾:疟疾是一种疾病.经过修改的玻璃碳电极有分子印记的聚合物.普鲁士蓝色纳米粒子 (PBNP) 是一种

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