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诊断前列腺癌的成像和积极监测:一篇评论
Thomas Li1, Sunny Nalavenkata2, Jonathan Fainberg2
1University of Sydney, Sydney, New South Wales, Australia.
JAMA surgery
|November 13, 2024
概括
前列腺癌的积极监测越来越多地使用多参数MRI (mpMRI). 虽然mpMRI有助于诊断和患者选择,但它还不能在监测期间取代活检,尽管生物标志物可能会减少活检频率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 积极监测 (AS) 是管理低至中等风险前列腺癌的关键策略.
- 多参数磁共振成像 (mpMRI) 越来越多地用于前检查途径进行前列腺癌诊断.
- 在AS患者选择中mpMRI的精确作用以及AS期间重复活检的必要性需要进一步定义.
研究的目的:
- 审查目前成像在前列腺癌的诊断和监测中的应用.
- 评估mpMRI在指导AS决策中的实用性以及成像用于减少活检频率的潜力.
主要方法:
- 对前列腺癌诊断和监测中的成像学当代文献的综述.
- 分析mpMRI在区分临床上显著的前列腺癌和不显著的前列腺癌中的作用.
- 评估风险计算器和新兴的成像技术,如前列腺特异性抗原正子辐射断层扫描/计算机断层扫描.
主要成果:
- mpMRI有效地区分疾病严重程度,并有助于为AS选择患者.
- 在mpMRI上可见的病变与更差的预后相关,告知风险分层.
- 目前的证据表明mpMRI不能取代AS期间的前列腺活检,因为缺失重大疾病的风险,但生物标志物可能有助于减少活检频率.
结论:
- 图像,特别是mpMRI,对于合理化AS中的活检至关重要.
- 需要进一步的前性研究和临床试验来规范报告,并澄清mpMRI在AS期间监测疾病进展中的作用.
- 风险计算器,当与成像和临床数据相结合时,可以改善AS患者分层.
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