癌症住院儿科患者的症状查:一项随机临床试验
L Lee Dupuis1,2,3, Donna L Johnston4, David Dix5
1Program in Child Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.
JAMA pediatrics
|November 13, 2024
概括
使用儿科症状查工具 (SSPedi) 的每日症状查显著降低了儿科癌症患者的症状负担. 与标准护理相比,这种方法改善了总症状得分,提高了患者的治疗体验.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 儿科医疗保健 儿科医疗保健
背景情况:
- 儿童癌症患者在治疗期间经常出现严重症状.
- 有效的症状管理对于改善这些患者的生活质量至关重要.
研究的目的:
- 评估每天的症状查和通过儿科症状查工具 (SSPedi) 的报告是否能减少儿科癌症患者的症状负担.
- 为了比较日常症状查与在医院或诊所设置的通常护理的有效性.
主要方法:
- 一个随机临床试验,涉及儿童癌症患者 (8-18岁) 需要每天至少5天住院或诊所.
- 参与者被分配到每天的SSPedi查,并向医疗保健团队报告或通常的护理.
- 数据分析包括比较第5天的SSPedi总得分,使用多重线性回归,并使用比例赔率模型分析二次结果.
主要成果:
- 与常规护理相比,每天的症状查在第5天显著改善了总症状负担得分 (调整后的平均差异: -2.5).
- 症状查降低了个体症状得分更高的可能性,15种症状中的8种症状显示出统计学上显著的减少.
- 虽然疼痛和生活质量得分没有显著差异,但随着查方案的实施,症状记录和干预率有所增加.
结论:
- 使用SSPedi工具进行每日症状查,有效降低儿科癌症患者的整体症状负担.
- 这种干预改善了症状管理和记录,有助于在治疗期间更好地照顾患者.
- 这些发现支持将系统性症状查纳入儿科瘤患者的常规护理.
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