酸盐-基网络涂层的组装具有可调节的特性,用于控制小分子的释放
Omid Mazaheri1,2, Zhixing Lin1,2, Wanjun Xu1
1Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia.
Advanced materials (Deerfield Beach, Fla.)
|November 13, 2024
概括
研究人员使用动态共价组件开发了新的酸网络 (SPN) 涂层. 这些响应pH的调节性涂层可提供受控释放的肥料和微量营养素,具有广泛的应用.
科学领域:
- 材料科学 材料科学 材料科学
- 表面化学 表面化学
- 纳米技术 纳米技术
背景情况:
- 定制材料的表面特性和释放特征对于各种应用至关重要.
- 开发用于可控封装和释放的坚固涂层仍然是一个重大挑战.
- 现有的方法往往缺乏针对特定货物交付所需的响应能力和鱼能力.
研究的目的:
- 通过使用动态共价协调组件,设计强大的,对pH值有反应的,可调节的基于酸盐的涂层.
- 为了证明这些酸网络 (SPN) 涂层对肥料和微量营养素的可控释放能力.
- 探索SPN涂料在农业和其他领域 (如隔离和医疗设备) 的潜力.
主要方法:
- 使用动态共价协调组装策略与甲酸盐和联体 (酸,酸,醇) 来创建SPN涂层.
- 功能化后的SPN涂层含有疏水性酸盐 (propyl, octyl, lauryl 酸盐) 来调整疏水性.
- 在不同的条件下,研究了尿素和微量营养素肥料 (Si,Fe3+,Cu2+,Zn2+) 的pH反应性和受控释放.
主要成果:
- 成功设计了具有可调节的疏水能力的强大,对pH值敏感的SPN涂层.
- 在土壤中控制释放尿素的证明长达7天 (依赖pH) 和14天 (依赖水性).
- 开发了一种用于持续释放和金属离子 (分别长达28天和14天) 的多用途输送系统.
结论:
- SPN涂层为控制和持续释放应用提供了一个多功能平台.
- SPN涂料的pH响应性和可调节的疏水性使得可定制的输送配置文件成为可能.
- SPN涂层显示出农业应用的巨大潜力,包括肥料和微量营养素的输送,以及其他领域.
相关概念视频
Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...


