产后生长轨迹和中年阻塞性睡眠呼吸暂停的风险:一个队列研究
Tejas Menon Suri1, Sumit Bhargava2, Kappadan Tharammal Akshara3
1Department of Pulmonary, Critical Care & Sleep Medicine, Sitaram Bhartia Institute of Science & Research, New Delhi, India.
Pediatric pulmonology
|November 13, 2024
概括
儿童的快速增长,特别是早期的体重和体重,增加了成年后患阻塞性睡眠呼吸暂停 (OSA) 的风险. 这种关联与成人BMI较高有关.
科学领域:
- 儿科生长与发展 儿科生长与发展
- 睡眠医学 睡眠医学
- 心脏代谢健康状况
背景情况:
- 儿童肥胖是成人心脏代谢疾病的前体.
- 阻塞性睡眠呼吸暂停 (OSA) 与肥胖有很强的联系.
- 目前尚不清楚OSA风险的发育起源.
研究的目的:
- 调查童年产后生长模式与成年期阻塞性睡眠呼吸暂停 (OSA) 风险之间的关联.
- 确定可能影响未来OSA风险的儿童成长的特定时期.
主要方法:
- 来自新德里出生队列研究的人类测量数据的分析.
- 逻辑回归模型用于评估婴儿,幼儿和晚年儿童期间的条件生长参数 (身高,体重,BMI) 的OSA风险 (由柏林问卷定义).
- 对潜在的混因素进行控制的多变量分析.
主要成果:
- 成年人患OSA的高风险与婴儿和幼儿时期更高的条件体重指数 (BMI) 相关.
- 儿童早期增加的条件体重增加也与较高的OSA风险有关.
- 当肥胖标准被排除在OSA定义之外时,成人BMI成为重要因素,而不是儿童生长参数.
结论:
- 儿童早期加速条件BMI和体重增加与中年阻塞性睡眠呼吸暂停 (OSA) 的风险增加有关.
- 成年人达到较高的BMI调解了童年成长和成年人OSA风险之间的关系.
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