鼻节功能障碍的家族风险表明心脏起器植入:全国性的队列研究
Morten Krogh Christiansen1,2, Erik Thorlund Parner3, Jens Brock Johansen4
1Department of Cardiology, Viborg Regional Hospital, Heibergs alle 2K, DK-8800 Viborg, Denmark.
概括
需要起器的鼻节功能障碍 (SND) 患者的一级亲属患有SND的风险更高. 在家庭成员中早期植入心脏起器与亲属的风险和死亡率增加有关.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 鼻节功能障碍 (SND) 是心脏节奏的常见迹象.
- 人们怀疑对SND的遗传倾向,但尚未确立.
研究的目的:
- 调查需要起器的SND患者的SND一级亲属的SND风险和死亡率.
- 评估心脏起器植入的年龄对亲属疾病风险的影响.
主要方法:
- 全国基于登记的研究使用丹麦登记 (民事登记,国家患者,心脏起器和ICD).
- 其次是1954年 (1982-2022) 以后出生的人数为6,027,090人.
- 分析了2477个心脏起器植入物用于SND.
主要成果:
- 与一般人群相比,一级亲属患心脏起器治疗SND的风险增加了2.9倍.
- 风险与指数人植入年龄 (RR=5.5 ≤60年) 反比例.
- 总体死亡率类似,但早期发病的SND患者的亲属的死亡率更高 (RR=1.22 ≤60年).
结论:
- SND患者的一级亲属面临着SND的高风险.
- 亲属中SND的风险与指数患者心脏起器植入的年龄相反相关.
- 虽然整体死亡率相似,但家庭成员早期发病的SND可能会增加亲属的死亡风险.
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