在外部球体中,Arkypallidal神经元可以通过改变状体中的竞争来调节抑制控制
Cristina Giossi1,2, Jyotika Bahuguna3, Jonathan E Rubin4,5
1Departament de Ciències Matemàtiques i Informàtica, Universitat de les Illes Balears, Palma 07122, Spain.
概括
外部白色球体 (GPe) 通过调节皮质 - 基底 - thalamic电路中的抑制信号来调节动作取消. 状状路径削弱了直接路径的主导地位,增强了间接路径控制以停止行动.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 反应性抑制控制对于生存至关重要.
- 传统上,超直接途径被认为是皮质控制抑制作用的唯一途径.
- 新出现的证据表明,外部白色球体 (GPe) 在通过上升途径调节抑制控制方面发挥了作用.
研究的目的:
- 为了研究状状状通路在抑制作用中的作用.
- 为了检查外层白色球体 (GPe) 如何在皮层-基底 - thalamic (CBGT) 电路内调解抑制信号.
- 了解arkypallidal神经元对抑制控制的贡献.
主要方法:
- 使用了CBGT电路的生物约束尖端模型.
- 结合了来自arkypallidal神经元的发源白三角形通路.
- 进行了实验,探测了体下核 (STN),骨细胞和间接通路棘状投射神经元之间的相互作用.
主要成果:
- 在CBGT电路中,GPe对CBGT电路中的上升和下降抑制信号起着至关重要的调解作用.
- 发现状状状路径削弱了直接路径在证据积累中的主导地位.
- 这种调制增加了间接途径对基底 output 的相对抑制作用,从而促进了行动取消.
结论:
- 帕利多斯特里亚特途径在反应性抑制控制中发挥着重要作用.
- GPe对双向信息流的调解是管理行动取消的关键.
- 这项研究完善了我们对决策和行动抑制背后的神经回路的理解.
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