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Updated: Jun 7, 2025

Biolistic Transformation of a Fluorescent Tagged Gene into the Opportunistic Fungal Pathogen Cryptococcus neoformans
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Biolistic Transformation of a Fluorescent Tagged Gene into the Opportunistic Fungal Pathogen Cryptococcus neoformans

Published on: March 19, 2015

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在Cryptococcus neoformans中失去RNA干扰后,不同的进化轨迹

Jun Huang1, Connor J Larmore1, Shelby J Priest1

  • 1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.

Proceedings of the National Academy of Sciences of the United States of America
|November 13, 2024
PubMed
概括

像Cryptococcus neoformans这样的微生物中RNA干扰 (RNAi) 的损失可以实现快速适应. 这项研究揭示了RNAi损失是常见的,可以通过转位子活性导致高突变和耐药性,或允许没有它的生存.

关键词:
在KDZ转换后抗真菌药物耐药性 抗真菌药物耐药性过度突变是一种超级突变.

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