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USP1对PARP1进行二氧化,以调节其捕获和PARylation活动

Anna Nespolo1, Linda Stefenatti1, Ilenia Pellarin1

  • 1Molecular Oncology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, National Cancer Institute, Aviano (PN), Italy.

Science advances
|November 13, 2024
PubMed
概括

多 (ADP-ribose) 聚合酶抑制剂 (PARPi) 是有效的卵巢癌治疗方法. 准USP1/PARP1相互作用可增强癌细胞死亡,为敏感和耐药瘤提供新的治疗策略.

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