患有肌痛性骨髓灰质炎的患者的言语是否在4年内下降?
Annelise Ayres1, Marina Martins Pereira Padovani1,2, Maira Rozenfeld Olchik3,4,5,6
1Centro de Estudos da Voz - CEV - São Paulo (SP), Brasil.
肌痛性骨髓灰质炎 (MG) 患者的言语模式在四年内下降,肌痛性骨髓灰质炎增加,呼吸,发声和关节功能恶化,尽管整体健康状况稳定.
科学领域:
- 神经学 神经学
- 语音语言病理学 语言病理学
- 临床研究 临床研究
背景情况:
- 骨髓灰质炎 (MG) 是一种慢性自身免疫神经肌肉疾病,其特征是波动的软弱.
- 发言和声音障碍,如失联症,很常见,但在MG患者中往往被低估.
- 纵向研究对于了解MG语言缺陷的进展至关重要.
研究的目的:
- 在四年内纵向比较肌痛性骨髓灰质炎 (MG) 患者的言语和声音模式.
- 为了将语音和声音变化与临床疾病方面相关联.
- 评估失关节症的进展及其对呼吸道,声道和关节子系统的影响.
主要方法:
- 一项为期4年的纵向研究,涉及10名MGG患者和10名对照人群,根据年龄和性别进行了匹配.
- 临床评估包括定量肌痛严重症 (QMG) 评分,MGFA分类和MG-QoL.
- 语音任务在声学和感知上进行了分析;声学分析侧重于发音模式和声音质量.
主要成果:
- MG参与者表现出稳定的健康状况,但增加了轻度/中度肌痛性关节炎 (40%至90%).
- 在MG患者的呼吸,声声和关节子系统中观察到显著的恶化.
- 声学分析显示,言语速度下降 (p=0.047),发音速度下降 (p=0.007),动增加 (p=0.022).
结论:
- 骨髓灰质炎患者在四年内经历了言语衰退和发病症的增加.
- 尽管临床状况稳定,但潜在的语音子系统 (呼吸,声声,关节) 恶化.
- 在MG中,语音模式和临床严重程度或运动尺度之间没有发现显著的相关性.
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