血管风险与严重与非严重中风的关联:对INTERSTROKE研究的分析
Catriona Reddin1, Michelle Canavan1, Graeme J Hankey1
1From the HRB Clinical Research Facility Galway (C.R., M.C., C.J., M.J.O.), School of Medicine, University of Galway; Wellcome Trust-HRB (C.R.), Irish Clinical Academic Training, Dublin, Ireland; Institute of Health Informatics (C.R.), University College London, United Kingdom; Perron Institute Chair in Stroke Research (G.J.H.), Medical School, The University of Western Australia; Perron Institute for Neurological and Translational Science (G.J.H.), Perth, Australia; Rush Alzheimer Disease Research Center (S.O.), Rush University Medical Center, Chicago, IL; Academic Section of Geriatric Medicine (P.L.), Glasgow Royal Infirmary, University of Glasgow, United Kingdom; Beijing Hypertension League Institute (X.W.), China; Health and Medical Sciences (H.K.I.), University of Copenhagen, Denmark; Faculty of Medicine (F.L.), Universidad de La Frontera, Temuco, Chile; King Saud University (F.A.-H.), Riyadh, Saudi Arabia; Institute of Psychiatry and Neurology (A.C.), Warsaw, Poland; Department of Internal Medicine (A.O.), Faculty of Medicine, Istanbul Medeniyet University, Turkey; Sahlgrenska University Hospital and Sahlgrenska Academy (A.R.), University of Gothenburg, Sweden; St Johns Medical College and Research Institute (D.X.), Bangalore, India; and Population Health Research Institute (S.Y., M.J.O.), Hamilton Health Sciences and McMaster University, Ontario, Canada.
高血压,心房动和吸烟等危险因素与严重的中风有更强烈的联系. 相反,更高的腰部和部比率与不严重的中风更相关,为公共卫生战略提供了信息.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 急性中风导致各种功能障碍.
- 了解中风严重程度对风险因素的重要性对于有针对性的公共卫生干预至关重要.
研究的目的:
- 为了调查单个中风风险因素的影响是否随着中风的严重程度而变化.
- 为旨在减少中风相关残疾的公共卫生战略提供信息.
主要方法:
- 该研究分析了来自32个国家的13460名第一次急性中风患者的数据 (2007-2015年).
- 使用修改的兰金度量表 (mRS) 评估中风的严重程度,严重的中风定义为mRS 4-6.
- 使用多项逻辑回归和匹配的案例分析来比较风险因素与严重与非严重中风的关联.
主要成果:
- 高血压,心房动和吸烟与不严重的中风 (mRS 0-3) 相比,与严重的中风 (mRS 4-6) 有更强的关联.
- 具体来说,对于这些因素来说,严重中风的几率比率更高.
- 增加腰部和部的比率与非严重的中风有更强烈的关联.
结论:
- 高血压,心房动和吸烟不成比例地与更严重的中风结果有关.
- 较高的腰与部比率与较不严重的中风有关.
- 调查结果强调,需要根据风险因素概况和中风严重程度制定量身定制的公共卫生方法.
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