肥胖会影响多发性硬化症患者的疾病活动和进展,认知功能和生活质量
Jing Wu1, Lars Alfredsson1, Tomas Olsson1
1From the Aging Research Center (J.W.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Institute of Environmental Medicine (L.A.), Karolinska Institutet; Centre for Occupational and Environmental Medicine (L.A.), Region Stockholm; and Department of Clinical Neuroscience (L.A., T.O., J.A.H., A.K.H.), Karolinska Institutet, Stockholm, Sweden.
肥胖与多发性硬化症 (MS) 的进展速度更快,生活质量恶化和认知能力下降有关. 超重和肥胖也会增加MS患者的MRI活动.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 肥胖是多发性硬化症 (MS) 发展的一个已知的危险因素.
- 身体质量指数 (BMI) 对MS疾病进展的影响尚未完全理解.
研究的目的:
- 调查BMI如何影响MS疾病活动和进展.
- 评估BMI对MS患者认知表现和健康相关生活质量的影响.
主要方法:
- 一项基于人口的病例控制研究,对3,249名MS患者进行了诊断时按BMI分类.
- 10多年来,通过瑞典MS登记处进行了跟进.
- 使用线性混合和考克斯回归模型分析扩展残疾状态量表 (EDSS),MS影响量表29,符号数字模式测试和MRI数据.
主要成果:
- 肥胖与EDSS分数的年增速更快以及达到EDSS 3和4的风险更高相关.
- 超重和肥胖与MRI病变活动增加以及身体和心理恶化的风险增加有关.
- 肥胖与认知障碍恶化的风险增加1.51倍有关.
结论:
- 肥胖与加速的MS疾病进展有关.
- 较高的BMI会对MS患者的健康相关生活质量和认知功能产生负面影响.
- 超重和肥胖有助于增加疾病活动,由MRI发现证明.
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