探索来自欧洲选定的国家入侵性血清组B脑膜炎球菌菌株中的H因子结合蛋白的序列多样性和表面表达

Stephen A Clark1, Laura Willerton1, Heike Claus2

  • 1Meningococcal Reference Unit, UK Health Security Agency, Manchester Royal Infirmary, Manchester, UK.

PubMed
概括

大多数侵入性B组脑膜炎球菌菌株表达高水平的H结合因子蛋白 (fHbp),对疫苗有效性至关重要. 对451个菌株的分析显示,92%的疫苗超过了MenB-fHbp疫苗疗效的值.

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