默认模式网络的功能障碍激活在精神分裂症的响应抑制中
Menahem Krakowski1, Matthew J Hoptman1, Pal Czobor2
1Clinical Research Division, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA; New York University School of Medicine, Department of Psychiatry, New York, NY, USA.
精神分裂症患者因功能障碍默认模式网络 (DMN) 激活而表现出受损的响应抑制. 他们的大脑在任务中无法关闭DMN,突出显示DMN.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症与认知障碍有关,特别是在反应抑制方面.
- 默认模式网络 (DMN) 与精神分裂症的认知缺陷有关,有证据表明抑制功能受损.
- 了解DMN功能障碍对于解决精神分裂症认知缺陷至关重要.
研究的目的:
- 在响应抑制任务期间,对精神分裂症患者的功能障碍大脑激活的特征.
- 研究默认模式网络 (DMN) 在精神分裂症中受损反应抑制中的作用.
- 使用fMRI比较精神分裂症患者和健康对照者的大脑活动.
主要方法:
- 功能磁共振成像 (fMRI) 用于测量大脑活动.
- 84名受试者 (44名精神分裂症患者,40名健康对照) 进行了Go NoGo反应抑制任务.
- 参与者还接受了精神症状和视觉记忆评估.
主要成果:
- 精神分裂症患者在响应抑制任务上的表现较差,犯错误的次数更多.
- 与对照人群相比,fMRI显示精神分裂症患者在DMN区域 (前,前前,副海马体,胰岛) 的激活显著更高.
- 这种增强的激活表明在执行任务时无法关闭DMN.
结论:
- 在精神分裂症中,DMN功能障碍,特别是无法关闭,是阻断精神分裂症反应受损的关键因素.
- 在DMN中的干扰对于精神分裂症中观察到的认知障碍至关重要.
- 针对DMN活动可能为精神分裂症认知缺陷提供治疗潜力.
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