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母亲暴露于多环芳和出生人类学结果之间的关联:系统性审查和元分析
Ali Mohammad Latifi1, Fatemeh Abdi2, Mohammad Miri3
1Medical Biotechnology, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Ecotoxicology and environmental safety
|November 13, 2024
概括
母亲接触多环芳 (PAH) 与不良出生结果有关,包括出生体重和长度较低. 需要进一步的研究,以了解PAH代谢物的具体影响,并制定干预措施.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 儿科健康 儿科健康
背景情况:
- 以前的研究表明,产前多环芳 (PAHs) 暴露与不良出生人体测量结果之间存在联系.
- 现有证据是相互矛盾的,需要对研究进行全面的综合.
研究的目的:
- 系统地审查和元分析孕妇在怀孕期间暴露于PAHs与各种出生人类学结果之间的关联.
- 巩固PAHs对妊娠年龄相对小 (SGA),低出生体重 (LBW),出生体重 (BW),出生长度 (BL),出生头周长 (BHC) 和出生胸围 (BCC) 的影响的证据.
主要方法:
- 在主要数据库 (Scopus,PubMed/MEDLINE,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2024年7月1日.
- 包括来自5499篇文章初步选的27项研究.
- 随机效应元分析被用来估计关联,使用NOS和GRADE框架评估质量.
主要成果:
- 母亲的PAH暴露与低出生体重 (LBW) 没有显著的关联.
- 发现与降低出生体重 (BW) 和降低出生长度 (BL) 有显著的关联,两者都表现出高异质性.
- 观察到出生时头周长 (BHC) 的边界显著下降,没有显著的异质性. 对于妊娠年龄 (SGA) 小的结果不一致.
结论:
- 孕产妇暴露于PAH与不良的出生人类测量结果有关,特别是较低的出生体重和长度.
- 观察到的出生头周长的减少需要进一步调查,但目前尚未确定.
- SGA结果的变化凸显了复杂性;对特定PAH代谢物和干预措施的进一步研究至关重要.
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