没有BPA的吗? 探索BPA替代品BPS和BPF在子宫内膜脱胎的生殖毒性
Yao Xiong1, Shaoyuan Xu2, Ziwei Wang1
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei 430071, China; Wuhan Clinical Research Center for Reproductive Science and Birth Health, Wuhan, Hubei 430071, China.
Ecotoxicology and environmental safety
|November 13, 2024
概括
双A (BPA) 和其替代品双S (BPS) 和双F (BPF) 破坏子宫内膜的分泌和受体. 这些化学物质通过抑制细胞增殖和改变不孕妇女的关键分子通路来损害生殖健康.
科学领域:
- 生殖生物学和毒理学.
- 内分泌学 在内分泌学.
- 环境健康 环境健康
背景情况:
- 双甲 (BPA) 暴露与不良健康结果有关,导致开发无BPA产品.
- 然而,像Bisphenol S (BPS) 和Bisphenol F (BPF) 这样的替代品越来越普遍,检测水平与BPA相当.
- 以前的研究发现BPA是一种影响生殖和发育系统的内分泌干扰物.
研究的目的:
- 研究BPA,BPS和BPF对子宫内膜决定和受体性的影响.
- 在接受辅助生殖技术 (ART) 的不孕妇女的血清样本中分析这些双的存在.
- 探索BPA及其替代品的生殖毒性背后的分子机制.
主要方法:
- 在接受ART的不孕妇女的血清样本中检测BPA,BPS和BPF.
- 在激素诱导脱产后,人类子宫内膜层细胞暴露于不同度的BPA,BPS和BPF.
- 细胞增殖 (CCK-8),分子标记物,基因表达 (RT-qPCR,转录组测序) 和代谢物 (非向代谢物) 的评估.
主要成果:
- 在不育的患者中,血清BPS水平明显高于BPA,特别是在复发性植入失败 (RIF) 组.
- 乙A及其替代品抑制了子宫内膜层细胞的增殖,并减少了决定性标记物.
- 在暴露于BPA,BPF和BPS后,观察到不同的代谢物和基因表达,影响包括谷氨代谢,氨酸生物合成和信号通路在内的途径.
结论:
- 双A及其替代品 (BPS,BPF) 呈现出生殖毒性,显著影响子宫内膜分泌和受体性.
- 这些发现凸显了在接受ART的不孕妇女中与BPA替代品相关的潜在风险.
- 需要进一步的研究,以阐明生殖健康影响的全部范围,并制定减轻暴露的策略.
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