人体皮肤的多样性 三维器官类型培养的多样性
Yunlong Y Jia1, Scott X Atwood2
1Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Current opinion in genetics & development
|November 13, 2024
概括
人体器官类型培养 (OTC) 仍然是组织工程中主要的3D皮肤模型,因为它们的成本效益和准确性. 本综述详细介绍了OTC最近取得的进展,以改善体外皮肤模型的真实性.
科学领域:
- 组织工程是组织工程.
- 皮肤病学 皮肤病学
- 再生医学是一种再生医学.
背景情况:
- 已经出现了先进的皮肤工程模型,如3D生物打印和皮肤芯片系统.
- 在20世纪70年代开发的人体器官样式培养 (OTCs) 仍然是主要的体外3D皮肤模型.
- OTCs因其成本效益,易用性,速度和对原生人类皮肤的准确表示而受到青.
研究的目的:
- 系统地审查人类器官类型皮肤培养 (OTC) 的最新进展.
- 为增强体外皮肤模型的真实性和可重复性提供见解.
- 突出OTC在皮肤组织工程中的持续相关性.
主要方法:
- 对皮肤器官类型培养 (OTC) 的最新文献进行系统审查.
- 在OTC模型开发中分析技术和创新.
- 将OTC与较新的体外皮肤模型进行比较.
主要成果:
- 最近的进展显著提高了皮肤器官类型培养的忠实性.
- 尽管采用了较新的技术,但OTC仍保持着其在体外皮肤模型领域的领先地位.
- 导致OTC普及的关键因素包括成本效益,简单性和速度.
结论:
- 人类器官型培养 (OTC) 仍然是皮肤组织工程中的重要工具.
- 目前正在进行的研究重点是进一步提高OTC模型的能力.
- 在OTCs的进步有助于改善用于研究和开发的体外皮肤建模.
相关概念视频
Tissues
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Cell Diversity
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Multicellular organisms...
Cellular Differentiation
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...


