早期术后血清Sirtuin 1预测老年患者的术后认知功能障碍
Jinshan Shi1, Haibo Chen1, Yujie Zhang1
1Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
The Journal of surgical research
|November 13, 2024
概括
早期术后的Sirtuin 1 (SIRT1) 水平有效预测心脏手术后的术后认知功能障碍 (POCD). 较低的SIRT1表明POCD风险较高,有助于在接受心肺旁路术的患者中早期检测.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 手术后认知功能障碍 (POCD) 是心脏手术后的常见并发症,特别是在使用心肺旁路 (CPB) 的老年患者中.
- 赛尔图因1 (SIRT1) 与缓解POCD有关,但其作为预测生物标志物的作用尚未完全理解.
研究的目的:
- 调查Sirtuin 1 (SIRT1) 作为术后认知功能障碍 (POCD) 的预测生物标志物的潜力,用于接受心肺旁路 (CPB) 心脏手术的患者.
主要方法:
- 接受CPB心脏手术的患者使用蒙特利尔认知评估对POCD进行了评估.
- 分析了POCD的风险因素,接收器操作特征 (ROC) 曲线分析评估了早期术后血清SIRT1水平的预测能力.
主要成果:
- 年龄,教育,CPB持续时间,大动脉闭塞持续时间,麻醉持续时间和早期术后血清SIRT1水平与POCD有显著的关联.
- 在POCD患者中观察到较低的早期术后血清SIRT1水平.
- SIRT1显示出高灵敏度和特异性作为POCD的预测因子. 在POCD患者中,神经元特异性酶和S100β水平升高,与SIRT1.1相反相关.
结论:
- 早期术后血清SIRT1是一种敏感和特定的生物标志物,用于预测心脏手术患者的POCD.
- 测量SIRT1可以帮助预测POCD的临床发作.
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