根据双下巴减少的新方法进行脂肪细胞亡:试点人类组织学研究
1Division of Schweiger Dermatology, New York, NY, USA.
Journal of cosmetic dermatology
|November 13, 2024
概括
这项研究表明,非侵入性HIFES和Sync RF+治疗有效地通过诱导脂肪细胞亡来减少脑下脂肪. 该程序对患者来说是安全和舒适的,没有报告任何不良事件.
科学领域:
- 审美学 在审美学方面
- 皮肤病学 皮肤病学
- 医疗技术 医疗技术 医学技术
背景情况:
- 脑下充满,或"双下巴",影响男性和女性,影响被认为的吸引力.
- 结合高强度聚焦电刺激 (HIFES) 和同步射频 (Sync RF+) 的非侵入性治疗,准皮肤,脂肪组织和消化肌肉,以减少下层脂肪.
研究的目的:
- 为了研究脂肪组织的组织学变化,包括细胞形态和细胞亡标志物 (caspase-7, Bcl-2),在HIFES和Sync RF+治疗后.
- 为了评估这种联合的非侵入性技术的安全性和有效性,用于下部脂肪的减少.
主要方法:
- 在活跃组 (n=6) 中,一次20分钟的治疗被施加到脑下部区域.
- 皮下脂肪活检是在治疗开始时,24小时和治疗后7天收集的,用于组织学和免疫组织化学分析.
- 评估了脂肪细胞形态的变化,酶-7和BCL-2水平.
主要成果:
- 治疗后,卡斯帕-7水平显著增加 (24小时时511%,7日时101%) 和BCL-2水平下降 (24小时时89%,7日时24%),表明了细胞亡.
- 脂肪细胞显示缩小和失去形状的均性.
- 在6名受试者中,5名受试者接受了舒适的治疗,没有观察到任何不良事件.
结论:
- 非侵入性的HIFES和Sync RF+技术诱导脂肪细胞亡,从而导致下层脂肪的减少.
- 综合处理表明,在美学应用中,安全性概况有利.
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