Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

9.3K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.3K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

4.2K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
4.2K
Protein Folding01:22

Protein Folding

117.4K
Overview
117.4K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Protein and Protein Structure02:15

Protein and Protein Structure

78.6K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
78.6K
Actin Filament Depolymerization01:19

Actin Filament Depolymerization

3.0K
Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...
3.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Nonlinear Relationships of Fibrin Network Structure as a Function of Fibrinogen and Thrombin Concentrations for Purified Fibrinogen and Plasma Clots.

Acta biomaterialia·2026
Same author

Development of Miniprotein Binders to Inhibit VEGF-Induced Corneal Neovascularization.

Investigative ophthalmology & visual science·2026
Same author

Blood product supplementation modulates clotting kinetics, mechanics, and fibrin architecture in an in vitro model of trauma-induced coagulopathy.

Thrombosis research·2026
Same author

Plasma Proteomic Signatures of Coagulopathy Following Traumatic Injury: Links to Biomechanics and Patient Outcomes.

Shock (Augusta, Ga.)·2026
Same author

When hydrophobic surfaces rewrite the chorography of fibrinogen.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Characterizing the impact of traumatic brain injury phenotype on coagulation dynamics in severely injured patients.

Thrombosis research·2026
Same journal

The Natural Mutation Arg221aTrp in Human α-Thrombin Abrogates Physiological Na<sup>+</sup> Binding and Preferentially Hinders the Protease Anticoagulant Functions.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

A historical review of the biological, semantic and clinical aspects of aspirin resistance.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Association between Thrombus Neutrophil Extracellular Traps Content and Ischemic Stroke Recurrence.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Peptide-Mediated Inhibition of Surface-Initiated Thrombogenesis.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Growth differentiation factor-15 and bleeding risk in patients with venous thromboembolism.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Physiological Anticoagulant Deficiencies: Pathogenesis, Diagnosis, and Clinical Implications.

Journal of thrombosis and haemostasis : JTH·2026
查看所有相关文章

相关实验视频

Updated: Jun 7, 2025

Analysis of &#946;-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

9.1K

解构纤维素的结构.

Rebecca A Risman1, Mehmet Sen2, Valerie Tutwiler3

  • 1Department of Biomedical Engineering, Rutgers University, New Brunswick, New Jersey, USA. Electronic address: https://twitter.com/rebecca_risman.

Journal of thrombosis and haemostasis : JTH
|November 13, 2024
PubMed
概括
此摘要是机器生成的。

最近的研究揭示了纤维素原蛋白.

关键词:
血栓是血液中的一个凝块.纤维素纤维素是一种纤维素.纤维素原体是一种纤维原体.机械学 机械学组织工程是组织工程.

更多相关视频

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.4K
Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies
04:36

Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies

Published on: April 19, 2024

459

相关实验视频

Last Updated: Jun 7, 2025

Analysis of &#946;-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

9.1K
Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

11.4K
Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies
04:36

Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies

Published on: April 19, 2024

459

科学领域:

  • 生物化学和分子生物学
  • 生物材料科学 生物材料科学
  • 血液学 血液学 血液学

背景情况:

  • 纤维素和纤维素是血液凝固,伤口愈合和免疫力的关键蛋白质.
  • 了解它们的结构功能关系对于各种医疗应用至关重要.

研究的目的:

  • 审查纤维素素/纤维素结构及其与生理作用的联系最近 (24个月) 的进展.
  • 探索纤维素作为生物材料和治疗点的潜力.

主要方法:

  • 在过去24个月内发表的研究的文献综述.
  • 对纤维素素/纤维素结构,动态,修饰和特性研究的分析.

主要成果:

  • 纤维原体表现出动态形状灵活性,影响其功能和结合点.
  • 翻译后的修改和外部因素影响纤维素凝块的结构和形态.
  • 纤维素的机械特性对于凝块的稳定性和栓塞至关重要.
  • 纤维素作为一个多功能生物材料在组织工程.

结论:

  • 纤维素素/纤维素的结构动态支持其在健康和疾病中的多样性作用.
  • 对纤维素素/纤维素结构的进一步研究可能会导致新的治疗策略和生物材料应用.