通过代谢学来导航肝脏健康:全面的综述
Preetpal Singh1, Ravinder Singh1, Chirag Pasricha1
1Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Clinica chimica acta; international journal of clinical chemistry
|November 13, 2024
概括
代谢学为早期发现和治疗非酒精性脂肪性肝病 (NAFLD) 提供了一种有希望的非侵入性方法. 本综述强调了最近使用代谢学来发现肝脏疾病敏感和特定生物标志物的研究.
科学领域:
- 生物化学 生化学
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是全球慢性肝病的主要原因,影响人口的四分之一.
- 亚太地区占肝脏相关死亡率的重大负担.
- 目前的诊断方法如成像 (CT,NMR,超声波) 和肝活检都有局限性,包括侵入性和样本可变性.
研究的目的:
- 审查最近关于用于诊断肝脏疾病的代谢学研究.
- 探索代谢学在识别肝脏疾病的非侵入性生物标志物的潜力.
- 突出代谢学对早期疾病检测和治疗的好处.
主要方法:
- 用代谢学进行的最近研究的文献综述.
- 对肝脏疾病中的生物标志物发现的代谢学方法的分析.
- 代谢学与其他奥米克技术的整合.
主要成果:
- 代谢学在早期发现肝脏疾病方面表现有前途.
- 对肝纤维化和胆固醇症的非侵入性生物标志物的鉴定正在取得进展.
- 代谢学有助于理解疾病病理生理学和药物开发.
结论:
- 代谢学是诊断肝脏疾病,特别是NAFLD的宝贵工具.
- 这种方法提供了敏感和特定的生物标志物,克服了传统方法的局限性.
- 进一步研究代谢学可以显著改善早期诊断和肝脏疾病的管理.
相关概念视频
01:30Liver Physiology
442
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
442
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
79
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
79
01:27Liver Histology
604
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
604