胰岛素样生长因子-1和认知健康:探索细胞,临床前和临床维度
Cellas A Hayes1, Destiny Wilson2, Miguel A De Leon2
1Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Frontiers in neuroendocrinology
|November 13, 2024
概括
胰岛素样生长因子-1 (IGF-1) 与更好的认知功能和降低痴呆风险有关. 较高的IGF-1水平与细胞,临床前和临床研究中的认知能力改善有关.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 与年龄相关的认知衰退和痴呆症是严重的健康问题.
- 胰岛素样生长因子-1 (IGF-1) 在神经发育和成人大脑功能中起着至关重要的作用.
- IGF-1信号传递影响神经发生,炎症,髓化和突触可塑性.
研究的目的:
- 综合审查IGF-1与认知功能之间的关联.
- 评估IGF-1在细胞,临床前和临床水平上的作用.
- 综合目前关于IGF-1对认知和痴呆的影响的证据.
主要方法:
- 关于IGF-1和认知的研究的文献综述.
- 对IGF-1细胞信号机制的分析.
- 检查临床前动物模型 (老化和转基因).
- 对与IGF-1水平与认知表现相关的临床研究的评估.
主要成果:
- IGF-1通过其在神经元和质细胞上的受体表现出类信号传递.
- 在各种模型中,增加的IGF-1水平始终与改善的认知功能有关.
- 降低IGF-1水平,如在淘汰赛模型中所见,导致认知障碍.
- 临床研究主要显示高IGF-1和更好的认知之间存在正相关性.
结论:
- IGF-1 是维持整个生命的认知健康的关键因素.
- 年龄和IGF-1之间的反向关联可能会导致与年龄相关的认知衰退.
- 针对IGF-1信号的治疗策略可能有望预防或治疗认知障碍和痴呆症.
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