风险评估模型和肺动脉高血压的生存率:SPAHR分析
Clara Hjalmarsson1, Tanvee Thakur2, Tracey Weiss2
1Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
多元组件改善 (MCI) 和其他风险评分准确预测肺动脉高血压 (PAH) 患者的生存率. 实现更多的低风险标准改善了所有年龄段的无移植生存率.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 临床研究 临床研究
背景情况:
- 肺动脉高血压 (PAH) 存活预测对于患者管理至关重要.
- 多元组件改善 (MCI) 是预测PAH生存的新终点.
- 已建立的风险分层分数包括ESC/ERS四层风险 (4SR) 和法国风险分层分数 (FRS).
研究的目的:
- 调查MCI,4SR和FRS的预后价值,以预测瑞典PAH患者的无移植 (TF) 存活率.
- 评估这些风险预测模型在不同的年龄组 (<65岁和≥65岁).
主要方法:
- 来自瑞典PAH和CTEPH注册表 (SPAHR) (2008-2021) 的数据分析.
- 在诊断后6个月调查MCI,4SR和FRS.
- 使用Kaplan-Meier估计,Log-Rank测试和Cox比例模型进行生存分析.
主要成果:
- 多元组件改善 (MCI) 的成就独立预测了TF生存,当满足更多的MCI标准时,所看到的益处更大.
- 4SR和FRS都显示出与TF生存的强烈关联,较低的风险得分与更长的生存相关.
- 与年轻患者相比,65岁及以上的患者的基线风险更高,改善较少,TF存活率更差.
结论:
- 所有评估的模型 (MCI,4SR,FRS) 对PAH患者的TF生存具有预后相关性.
- 随着满足低风险标准的数量,风险预测逐渐得到改善.
- 这些风险评估工具在不同年龄段是有效的.
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