吸附性肺炎的细菌学:肺微生物组和不断变化的微生物病因学
Francois Fadell1,2, Ranime Saliba1,2, Ali A El-Solh1,2,3,4
1VA Western New York Healthcare System, Research and Development, Buffalo, New York.
吸气性肺炎与肺部细菌的变化有关,其中格拉姆阴性细菌变得越来越常见. 了解口腔微生物群的理解
科学领域:
- 肺部医学 肺部医学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 吸入性肺炎是由于吸入到肺中的分泌物而引起的炎症.
- 危险因素包括吞问题,咳反射不良和神经疾病.
- 吸入性肺炎的微生物景观正在发生变化,格拉姆阴性细菌的数量正在增加.
研究的目的:
- 审查吸入性肺炎不断变化的微生物学.
- 探索口腔微生物组与肺吸收之间的联系.
- 讨论针对微生物群的预防和治疗策略.
主要方法:
- 这是一个叙事评论.
- 它综合了有关吸入性肺炎微生物学的现有知识.
- 重基因组测序被强调为了解微生物组与宿主相互作用的关键技术.
主要成果:
- 厌氧细菌的重要性正在下降.
- 如今,格拉姆阴性细菌如大肠杆菌 (Escherichia coli),肺炎菌 (Klebsiella pneumoniae) 和气球菌 (Pseudomonas aeruginosa) 已经占主导地位.
- 吸收导致肺微生物群失调.
结论:
- 吸入性肺炎的微生物学正在发生变化,格拉姆阴性病原体的增加.
- 口腔微生物组在肺吸收中起着至关重要的作用.
- 对微生物组向治疗的进一步研究是有必要的.
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