银,铜和纳米颗粒悬浮液在深溶解剂中具有选择性和补充性抗微生物和抗病毒活性
Olga Długosz1, Anna Żebracka2, Marta Sochocka3
1Faculty of Chemical Engineering and Technology, Cracow University of Technology, Cracow, Poland; Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, Lublin, Poland.
Environmental research
|November 13, 2024
概括
在这项研究中,使用深度环氧溶剂合成了银,铜和纳米颗粒,显示出强大的抗菌和抗病毒活性. 这些纳米粒子通过产生活性氧物种,有效地对抗细菌,真菌和病毒.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物技术是生物技术.
背景情况:
- 金属和非金属纳米粒子具有固有的生物活性特性,对广泛的微生物有效.
- 深度环氧溶剂 (DES) 为纳米粒子合成提供了一种绿色化学方法,有可能提高它们的生物活性.
研究的目的:
- 使用贝他因-葡萄糖-乙烯基醇DES合成稳定的银 (Ag),铜 (Cu) 和 (Se) 纳米粒子.
- 为了评估合成纳米颗粒的抗菌和抗病毒功效.
- 调查纳米粒子诱导微生物失活的基础机制.
主要方法:
- 使用DES介质进行纳米粒子合成.
- 使用STEM,XPS,DLS和UV-VIS光谱学对纳米粒子进行表征.
- 抗菌试验包括MIC/MBC确定和ROS生成试验.
- 针对流感A/H1N1,HCoV-OC43和VSV的抗病毒试验.
主要成果:
- 稳定的Ag,Cu和Se纳米粒子 (50-100nm) 在DES中成功合成.
- 纳米悬浮物对黄金葡萄球菌,大肠杆菌和白菌有显著的生物活性.
- 铜纳米颗粒显示,对流感A/H1N1,HCoV-OC43和VSV的病毒标位减少超过93.7-99.96%.
- 作用机制涉及到活性氧物种 (ROS) 的产生,导致酶失活和代谢抑制.
结论:
- DES是生产稳定,生物活性纳米颗粒的有效介质.
- 合成的Ag,Cu和Se纳米颗粒显示出广泛的抗微生物和强大的抗病毒特性.
- 纳米颗粒的ROS生成能力是它们抗微生物和抗病毒机制的关键因素.
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