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Updated: Jun 7, 2025

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酸盐缓冲对mRNA-LNP的影响:探索超出一般关键质量属性的因素

Burcu Binici1, Ankita Borah1, Julie A Watts2

  • 1Strathclyde Institute of Pharmacy and Biomedical Sciences, 161 Cathedral St, University of Strathclyde, Glasgow, Scotland, G4 0RE, UK.

International journal of pharmaceutics
|November 13, 2024
PubMed
概括

酸盐缓冲度会影响mRNA-LNP转染. 较高的度降低了细胞吸收和体内表达,即使粒子大小和封装效率保持一致.

关键词:
这些言都是言.缓冲器缓冲器是一个缓冲器.在CQAs中,CQAs是什么?酸的使用方法脂质纳米颗粒的使用方法制造业 制造业 制造业 制造业它们是mRNARNA.

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