脂肪肝指数和喘风险之间的剂量反应关系:NHANES 2001~2018年
Tengfei Sun1, Kexin Fan2, Zhuoxiao Han2
1Department of Gastroenterology, The First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei, China.
Endocrine journal
|November 13, 2024
概括
这项研究揭示了成年人脂肪肝指数 (FLI) 和喘风险之间的非线性联系. 确定了男性和女性的最佳FLI值,可能降低喘发病率.
科学领域:
- 内部医学 内部医学
- 肺部病理学 肺部病理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肥胖和代谢问题与喘和脂肪肝有关.
- 喘和非酒精性脂肪性肝病 (NAFLD) 之间的联系仍未得到充分研究.
- 脂肪肝指数 (FLI) 是一个经过验证的NAFLD指标.
研究的目的:
- 调查喘风险和FLI之间的关联.
- 探索FLI对喘的剂量反应关系和值影响.
- 为了确定喘风险的性别特定的FLI值.
主要方法:
- 来自NHANES (2001-2018) 的16223名美国成年人的分析.
- 后勤回归用于评估FLI和喘风险.
- 非线性关系和值分析的受限制立方线 (RCS) 模型.
主要成果:
- 在FLI和喘风险之间发现了显著的非线性关系 (p < 0.05).
- 较高的FLI与喘风险增加有关,特别是在最高四分位数 (OR=1.48) 中.
- 男性的最佳FLI值为68,女性为63,与喘风险最低相关.
结论:
- 在FLI和喘风险之间存在非线性关联.
- 性别特定的FLI值可以帮助识别患喘风险较低的个体.
- 保持男性FLI低于68和女性FLI低于63对于预防喘可能是有益的.
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