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初级和转移性皮肤黑色素瘤之间淋巴状结构的病理,转录和预后影响的差异
Lilit Karapetyan1, Aofei Li2,3, Danielle Vargas De Stefano4,5
1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida, USA lilit.karapetyan@moffitt.org.
Journal for immunotherapy of cancer
|November 13, 2024
概括
淋巴结合体 (LA) 在黑色素瘤中很常见,并且与更好的结果有关. 在患有原发性黑色素瘤的患者中,LA的存在表明了改善的生存率和无瘤淋巴结状况.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLS) 在固体癌症中具有已知的预后价值.
- 淋巴结合物 (LA) 的作用,TLS的不成熟前体,在黑色素瘤中还不清楚.
- 这项研究调查了黑色素瘤中LA和TLS的特征和预后意义.
研究的目的:
- 确定黑色素瘤中LA和TLS的患病率和位置.
- 评估LA和TLS与黑色素瘤患者临床结果的相关性.
- 探索这些淋巴状结构中的细胞组成和基因表达.
主要方法:
- 分析了278个黑色素瘤患者样本 (原发性和转移性),使用H&E染色,多重免疫光学 (mIF) 和转录组分析.
- 评估LA和TLS的存在,位置和细胞组成 (CD20+,CD4+,CD8+细胞).
- 考克斯比例危险回归模型被用于评估预后值.
主要成果:
- 淋巴结合物 (LA) 在72%的黑色素瘤标本中被发现,通常在多个位置.
- 在11%的样本中观察到三级淋巴状结构 (TLS),主要是在转移病例中.
- LA的存在与改善的整体存活率 (OS) 和无瘤区域淋巴结状态 (p=0.01) 显著相关.
- 氨酸的存在与更高的化学激素基因表达相关,而缺席与色素/神经基因特征有关.
结论:
- 黑色素瘤经常在各种瘤微环境的位置内含有淋巴结合物 (LA).
- 在黑色素瘤患者中,LA的存在与改善整体存活率和更好的区域淋巴结状况有关.
- 在黑色素瘤中,LA可以作为一个有价值的预后生物标志物.
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