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由于Le^a和Le^b抗体而引起的血液溶解输血反应

Hai-Yan Li¹, Li-Jun Li², Deng-Shan Yang²

¹Department of Blood Transfusion, Wuming Hospital of Guangxi Medical University, Nanning, China lhy512moon@aliyun.com.

Annals of clinical and laboratory science

|November 13, 2024

概括

一名孕妇因罕见的易斯抗体 (抗-Le ^{a>和抗-Le ^{b>) 而经历了严重的输血反应. 这突显了对抗原阴性血液选择的需要,而不是对易斯抗体的标准交叉匹配.}}

科学领域:

输血医学输血医学
免疫学免疫学免疫学
产科产科产科产科产科

背景情况:

Thalassemia 和怀孕呈现独特的输血挑战 .
尽管有标准的交叉匹配,但急性溶血输血反应 (AHTR) 可能会发生.
易斯抗体通常被认为是临床上无关紧要的,可引起严重反应.

研究的目的:

为了调查在患有沙拉西米亚的孕妇患者中AHTR的原因.
突出路易斯抗体在输血反应中的临床意义.
在复杂的病例中强调最佳的血液选择策略.

主要方法:

患者病史审查和临床观察.
使用血型参考实验室 (BTRL) 进行血型和抗体鉴定.
对抗体特征 (IgM,IgG) 和输血结果的分析.

主要成果:

该患者在输血洗净的红细胞 (RBC) 后发展出AHTR.
调查显示存在抗Le ^a (IgM) 和抗Le ^b (IgM/IgG) 抗体.
这些抗体被确定为严重输血反应的原因.

结论:

易斯抗体的罕见组合可以导致临床显著的AHTRs.
对患有路易斯抗体的患者来说,抗原阴性血液选择至关重要.
当使用聚烯时,可能需要使用替代交叉匹配方法,这是由于易斯抗体的限制.

关键词:

路易斯抗体路易斯抗体泰拉塞米亚症是一种疾病.输血反应反应的发生.

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