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相关概念视频

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
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多样本图案发现和可视化,用于串联重复.

Yaran Zhang1, Marc Hulsman1,2, Alex Salazar1

  • 1Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081HV Amsterdam, The Netherlands.

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概括

莫蒂斯科普是一个新的工具,它使用长读测序分析人类基因组中的并列重复 (TRs). 它准确地识别了TR动机,有助于理解遗传变异和疾病.

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 串联重复 (TRs) 是显著的基因组区域易于变异.
  • TR变异与神经病理疾病和人口遗传学有关.
  • 短读测序限制了全面的TR分析.

研究的目的:

  • 介绍MotifScope,一种使用长时间读取数据进行TR特征的新算法.
  • 能够在多个样本和个体中准确地发现和比较动机.
  • 解决以前的TR分析方法的局限性.

主要方法:

  • 开发了MotifScope,这是一个基于de novo k-mer的算法,用于TR动机发现.
  • 综合型号发现与序列对齐用于交叉样本分析.
  • 使用长读序列数据进行全面的TR分析.

主要成果:

  • 莫蒂斯科普可以识别出比现有的工具更多的TR图案.
  • 该算法提供了更准确的重复序列的表示.
  • 证明了MotifScope在跨个体和内个体TR比较方面的能力.

结论:

  • MotifScope 增强了使用长读序列的协奏重复的分析.
  • 该工具在人口遗传学,临床诊断和法医学中提供了有价值的应用.
  • 莫蒂斯科普为研究TRs.的基因组变异提供了一个强大的方法.