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急性肺栓塞时的多流:特征和相关性
Nuria Rodríguez-Núñez1, Francisco Gude2,3, Lucía Ferreiro4,3
1Pneumology, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain nuria.rodriguez.nunez@sergas.es.
BMJ open respiratory research
|November 13, 2024
概括
在急性肺栓塞 (APE) 中,多流液 (PLEF) 增加了死亡风险的两倍. 双边的PLEF与单边的PLEF相比,死亡风险增加了四倍,突出了其在APE患者的临床意义.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 流 (PLEF) 是急性肺栓塞 (APE) 的常见并发症,但其完整的临床意义尚不清楚.
- 了解APE中PLEF的特征和预后影响对于患者管理至关重要.
研究的目的:
- 调查APE和PLEF患者的特征.
- 在APE中开发PLEF的预测模型.
- 评估PLEF对APE患者30天全因死亡率的影响.
主要方法:
- 对1602名接受APE治疗的患者进行了回顾性分析.
- 根据PLEF的存在和横向性对患者进行分类.
- 开发PLEF和30天死亡率的预测模型.
- 多变量分析以确定与PLEF和死亡率相关的因素.
主要成果:
- 在23.8%的APE患者中存在PLEF,并与更多的并发病,外围APE,肺梗塞和更高的死亡率有关.
- 与单边的PLEF相比,双边的PLEF与增加的并发症,严重程度和死亡率相关.
- 多变量分析确定了心房动,充血性心力衰竭,肺梗塞和高查尔森指数作为PLEF的预测因素.
- 死亡率的预测模型显示出良好的歧视 (AUC 0.89).
- 双边的PLEF使与APE相关的死亡风险增加了一倍 (OR 2.02),而双边的PLEF使其增加了四倍 (OR 4.07).
结论:
- 在APE患者中,很大一部分患有PLEF,这会影响临床结果.
- 在APE中预测死亡率的预测模型显示出良好的歧视力.
- 在APE患者中,PLEF的存在显著增加了死亡风险,双边输液具有最高风险.
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