在前性出生队列研究中,婴儿睡眠和神经发育之间的关联
Xianxian Zhu1, Yingying Zhang2, Bo Yang3
1State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China; Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Sleep health
|November 13, 2024
概括
婴儿睡眠问题,如频繁的夜间觉醒和长时间的睡眠开始延迟,与神经发育不佳有关. 总睡眠时间与婴儿发育结果没有显著的关联.
科学领域:
- 发育儿科 发育儿科
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 婴儿的睡眠模式对于健康的发育至关重要.
- 了解睡眠轨迹对神经发育的长期影响至关重要.
研究的目的:
- 检查婴儿睡眠模式和生活第一年的睡眠轨迹与神经发育结果之间的关联.
- 为了确定可能对婴儿发育构成风险的特定睡眠特征.
主要方法:
- 研究了中国3251名婴儿的队列.
- 睡眠参数使用婴儿睡眠简要问卷在42天,6个月和1岁时进行评估.
- 神经发育在1岁时使用贝利婴幼儿发育尺度,第三版进行评估.
- 潜伏变量增长曲线建模分析了睡眠轨迹 (总睡眠时间,夜间觉醒,睡眠开始的延迟).
- 普森回归评估了睡眠与神经发育之间的关联.
主要成果:
- 6个月的夜间频繁醒来与非最佳总运动发育的更高风险有关.
- 在1年内延长睡眠开始的延迟增加了非最佳精细和粗运动发育的风险.
- 经常在夜间醒来的一致轨迹增加了非最佳总运动发育的风险 (aRR,1.52).
- 睡眠开始延迟的轨迹增加与非最佳细体 (aRR,2.70) 和粗运动发育 (aRR,2.76) 的风险增加有关.
- 总睡眠时间及其轨迹与神经发育没有显著关联.
结论:
- 婴儿时期的特定睡眠问题和轨迹可能会增加神经发育受损的风险.
- 夜间醒来和睡眠开始的延迟是与运动发育风险相关的关键睡眠参数.
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