草甘在体外对海的淋巴细胞的影响
Maite De Maria1, Natalia Garcia-Reyero2, Nicole I Stacy3
1Department of Physiological Sciences, University of Florida, Gainesville, FL 32611, USA; Cherokee Nation System Solutions, Contractor to the United States Geological Survey- Wetland and Aquatic Research Center, Gainesville, FL, USA.
Environment international
|November 13, 2024
概括
暴露于草甘除草剂显著降低了佛罗里达海的T淋巴细胞免疫功能. 这种污染物可能会削弱海的免疫力,特别是当与环境压力因素相结合时.
科学领域:
- 环境毒理学环境毒理学
- 免疫学 免疫学 免疫学
- 海洋哺乳动物健康
背景情况:
- 草甘是一种广泛使用的除草剂,在海环境和血中发现.
- 当海暴露在污染物中时,它们表现出抑制的免疫功能.
- 了解草甘对海免疫力的影响对于保护至关重要.
研究的目的:
- 为了研究草甘对海T淋巴细胞增殖的影响.
- 用转录学分析,分析因草甘暴露而发生的基因表达变化.
- 评估草甘在环境相关度下对海的免疫反应的影响.
主要方法:
- 从自由活动的海中分离出周围血液单核细胞.
- 进行了T淋巴细胞增殖试验.
- 在体外对暴露于草甘的细胞进行了转录组分析.
主要成果:
- 暴露于草甘导致T淋巴细胞增殖的剂量依赖性减少.
- 在10,000μgL-1.1时,观察到大量的增殖减少.
- 转录组学揭示了急性阶段炎症基因的上调调节和T淋巴细胞通路的抑制.
结论:
- 暴露于草甘抑制了海T淋巴细胞的增殖,并改变了免疫基因表达.
- 环境压力因素可能会加剧草甘对海适应性免疫力的负面影响.
- 需要进一步的研究,以了解对这种危物种的长期影响.
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