伤害后手术对SDNN和创伤后应激障碍发展在两年内的影响
Jae-Min Kim1, Hee-Ju Kang2, Ju-Wan Kim2
1Department of Psychiatry, Chonnam National University Medical School, 160 Baekseoro, Dong-gu, Gwangju, 61669, Republic of Korea. jmkim@chonnam.ac.kr.
Scientific reports
|November 13, 2024
概括
低心率变化 (NN间隔的标准偏差 - SDNN) 预测了非手术创伤患者的创伤后应激障碍 (PTSD). 手术修改了这种关联,表明需要个性化的PTSD预防策略.
科学领域:
- 创伤研究研究创伤研究
- 心血管生理学心血管生理学
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 是身体伤害后的一个重大问题.
- 心率变化 (HRV),特别是NN间隔的标准偏差 (SDNN),是自主神经系统功能的标志物.
- 手术干预对HRV和PTSD发展之间的关系的影响尚不清楚.
研究的目的:
- 为了研究手术状态对SDNN和PTSD在身体受伤后发展之间的关联的修改效应.
- 为了确定基线SDNN是否可以预测PTSD风险不同于手术和非手术创伤患者.
主要方法:
- 一项前性队列研究,对538名身体受伤的患者进行了为期两年的随访.
- 基线评估包括SDNN (心率变化) 和手术状态.
- 使用临床医生管理的DSM-5PTSD尺度进行PTSD诊断,在受伤后的3,6,12和24个月.
- 使用后勤回归分析来检查关联和相互作用.
主要成果:
- 在24个月后,整体PTSD患病率为10.8%.
- 较低的SDNN与非手术患者的PTSD风险增加显著相关.
- 这种关联在受伤后3至12个月是显著的,但在24个月后没有显著.
- 在手术患者中,较低的SDNN和PTSD之间没有显著的关联.
结论:
- 手术状态显著改变了SDNN和PTSD发展之间的关系.
- 较低的SDNN可能作为非手术创伤幸存者的PTSD风险指标.
- 考虑SDNN和手术状态的量身定制的PTSD预防策略是有必要的.
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